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When Diarrhea Starts and How Long It Lasts Most people notice digestive changes within the first 37 days of starting tirzepatide or increasing their dose
In addition, the increased effort required to exhale can produce wheezing, while pursed lips or grunting respirations may signal efforts to keep the airways open by increasing pressure at the beginning of expiration (Crawford 2008
Tirzepatide works by reducing appetite, improving insulin sensitivity, and slowing digestion
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