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In addition, domestically developed candidates IBI324 and ASKG712 have entered phase I clinical trials, indicating platform maturity and feasibility of this target combination and providing a practical foundation for extension to solid tumors such as GBM
Still, larger studies, including patients from other parts of the world and a longer treatment period, are needed to validate methylcobalamins therapeutic effects in this subset of ALS patients, the authors noted.
Oxidative stress happens when free radicals outnumber the antioxidants available to neutralize them, which can lead to cellular damage over time
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