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In addition, reduced appetite may result in lower intake of essential nutrients such as calcium, vitamin D, and protein

Looking ahead, orforglipron and retatrutide from Eli Lilly exemplify the next generation of metabolic therapies: oral formulations that promise improved adherence and triple-hormone mechanisms that deliver superior weight loss [4]

Another study published a month earlier in JAMA Network Open found that people with Type 2 diabetes who used GLP-1s had a slightly increased risk of diabetic retinopathy