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People with metabolic syndrome, type 2 diabetes, and heart disease often have lower L-carnitine levels, making fat-burning more difficult and weight loss harder to achieve

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We propose that the effects of cumulative loss of surface receptor with fast-internalizing, slow-recycling, lysosome-targeting agonists, along with increases in -arrestin-induced desensitization, become more apparent with time, eventually overriding any positive effects associated with noncanonical signaling