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In this study, OCA can also significantly reduce the content of TG and hydroxyproline in the liver tissue of the model mice
2) Reduce peak to trough: Reduction in peak to trough allows for less minimum concentration exposure to achieve the desired long-term efficacy, which allows for less frequent dosing
They also found an inverse association between metabolic adaptation and weight loss after surgery, suggesting that the degree of metabolic adaptation might be one of the factors influencing the extent of weight loss post MBS [53]
The LEADER trial demonstrated a significant reduction in the rate of cardiovascular death, nonfatal MI, or nonfatal stroke in patients with type II diabetes treated with liraglutide
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