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BMC Ophthalmol 20:73
F12 P in GLP-1(9-36) is positioned in the TM1-TM2 cleft, stacking with Y145 1.40b , forming an aromatic hydrogen bond with D198 2.68b , and making hydrophobic contacts with K202 2.72b
Weight loss is the most visible change, with clinical trials demonstrating average reductions that vary by medication: approximately 5-10% with liraglutide (Saxenda), 15-17% with semaglutide 2.4mg (Wegovy) in the STEP trials, and up to 20% with higher doses of tirzepatide in the SURMOUNT programme
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