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TbpA and TbpB show considerable variation, particularly TbpB, whose molecular mass ranges from 68 to 85 kDa in different meningococcal isolates (Perkins-Balding et al., 2004)
The GHK-Cu group showed significantly greater total protein and collagen synthesis demonstrating that the peptide's effects on extracellular matrix accumulation extend to systemic injection, not just topical application
In contrast to other metabolic transformations, acetylation ends with less polar metabolite compared to the parent drug In some cases, the acetylated metabolite will be as active as the original drug
Of obvious relevance to our findings, GSTP1 has recently been shown to be an IL-6 target gene (Wang et al, 2010), while inhibition of GSTP1 activity by an IL-6 or IL-6 receptor mAb correlates with increased platinum (and paclitaxel) sensitivity in renal cancer cells (Mizutani et al, 1995)
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