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Tirzepatide already slows gastric emptying as part of its mechanism, meaning combining these effects could intensify nausea, constipation, or other gastrointestinal side effects in some patients
Because the peptide works with the body's repair processes, results tend to build over a cycle rather than appear overnight
Clinical trials found that 44% of patients on semaglutide 2.4 mg experienced nausea, 30% had diarrhea, and 25% had vomiting, all of which cause fluid loss
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