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Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens
Although historically used as an antihypertensive agent, clonidine is now primarily reserved for resistant hypertension and selected hypertensive emergencies
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