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It is particularly effective when combined with another topical prescription medication, tretinoin, to enhance its absorption (and means that it can be applied once daily versus the normal twice daily application, and without the use of microneedle devices)
*Note: Doses requiring more than 100 units may require two separate injections if using a 1 mL syringe
In addition, a clinical trial published in the journal Redox Report noted that the antioxidant alpha-lipoic acid has the ability to regenerate other antioxidants, including vitamin E, vitamin C, and glutathione
In native form, IGF-1 is tightly regulated by these proteins, limiting free circulating activity
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