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The improvement in kidney function was consistently observed in sensitivity analyses using alternative equations to estimate eGFR, but using the creatinine-based formulas, there was a statistically significant decrease in eGFR versus placebo at 12 weeks, which again reversed by 52 weeks, showing an improvement in eGFR with tirzepatide across all estimates (Extended Data Table 1)
full supply normalisation is expected by 2026
The maximum reductions in HbA 1c and bodyweight observed in the current study (18.72 mmol/mol [1.71%] and 8.4 kg, respectively) exceeded those of the above studies, after a shorter treatment duration of only 16 weeks
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