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Regarding the effect of GLP-1 on vascular endothelium, numerous in vitro studies and animal studies showed either nitric oxide-dependent or -independent vasodilative effects [121415192021]
Each injection is formulated to provide about one week of therapeutic effect, and steady state is reached after roughly 45 weekly doses, which helps explain why benefits feel smoother over time
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Gastrointestinal events were the most common adverse effect, dose-related and mostly mild to moderate, eased by starting low
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