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Elevated intracellular amphetamine also activates trace amine-associated receptor 1 (TAAR1), leading to protein kinase A (PKA) and protein kinase C (PKC) signaling and phosphorylation of DAT, NET, and SERT (Step 3)
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The cumulative effect of these factors - protection from digestive degradation, improved cellular uptake, sustained release, and reduced first-pass metabolism - is significantly enhanced bioavailability
It would have been great for our patients to have access to a safe, orally administered treatment with other potential benefits, Dr
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