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By incorporating more recent trials and stratifying results by rating scales, comparator groups, age, and dose, the present study provides a more granular, clinically interpretable synthesis

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Up to 55% of patients developed anti-drug antibodies [65], which were associated with systemic allergic reactions in approximately 5% of cases and injection-site hypersensitivity, including anaphylaxis, which necessitated early trial termination [66, 67]

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