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There are several ways to measure or estimate SMM (e.g
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accurate assessment requires imaging such as MRI, CT, or DEXA, or validated ultrasound, or clinical proxies such as fasting insulin, HOMA-IR, or serial waist measurements
Citation124 Moreover, many peptide drugs are not known to be substrates or inhibitors of transporters at present, indicating that transporter-mediated biliary or renal excretion may not be a major pathway for their elimination
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