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DMF/MMF actions may also be indirect, including blocking of cytokine-activated I-B, a cytoplasmic complex that can induce degradation of a NF-B inhibitor, releasing inflammatory transcription factors to the nucleus to induce inflammation

In these populations, discontinuation of GLP-1RAs before or during early pregnancy has been associated with greater gestational weight gain and, in some reports, less favorable pregnancy-related metabolic outcomes

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