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Retatrutide shows the highest weight loss in trials (28.7%), followed by tirzepatide (25%)
Amylin receptor agonism plays a central role in nutrient-sensing pathways that influence meal size, fullness signaling, and food intake
The honest answer is that it depends on the indication, and the timeline varies enough between tissue types that a single number is misleading
As noted, the present knowledge is limited, and these are considerations, not strong recommendations
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