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Moreover, a large-scale randomized controlled trial (RCTs) involving more than 17,000 individuals with obesity and cardiovascular disease demonstrated that semaglutide reduced the risk of cardiovascular death, myocardial infarction (MI), and stroke compared to the placebo 9
However: Sustained caloric reduction Rapid weight loss Reduced dietary diversity Pre-existing marginal status May increase vulnerability in certain individuals
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The outer ring depicts major hallmarks of aging that are positively modulated by GLP-1R signaling, including genomic instability, telomere attrition, epigenetic alterations, cellular senescence, stem cell exhaustion, chronic low-grade inflammation (inflammaging), insulin resistance, mitochondrial dysfunction, altered intercellular communication, dysregulated nutrient sensing, and microbiome dysbiosis
