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A 2020 study in Journal of Clinical and Aesthetic Dermatology found that combination therapy produced 23% greater melanin index reduction at 12 weeks vs hydroquinone monotherapy, with lower rebound rates at 6 months post-treatment
Reported issues with IV glutathione include allergic and skin reactions, and there is specific concern about the high doses used for cosmetic infusions, which run well above what the body produces naturally
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