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While BPC-157, TB-500, KPV, and GHK-Cu injections have not been studied for safety and efficacy in large-scale human clinical trials, some risks may be hypothesized from their mechanisms of action

Apart from TRPC channels, a role for ionotropic glutamate receptors for Ca 2+ entry has been suggested: NMDA receptors permeable to Ca 2+ accomplish Ca 2+ homeostasis [102, 103], and also AMPA receptors may be relevant as pharmacological AMPA receptor antagonism blunts Ca 2+ entry into erythrocytes in response to Cl - removal [104]

Current laboratory testing is required prior to administration

Counterargument: the higher CV is clinically insignificant for glutathione because the therapeutic window is wide