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Factors affecting oral exposure include: Peptide stability Capsule or tablet formulation Protection from digestive enzymes Timing Delivery system Intestinal inflammation PepT1 expression Targeted-release technology Commercial and clinic-based protocols report widely different oral quantities, which reflects the absence of a standardized formulation or validated human dose

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Glutathione is subsequently found at its highest concentrations in tissues at most risk and therefore requiring the most protection from potentially toxic exogenous and endogenous compounds: the liver where the vast majority of detoxification metabolism occurs and, at the cellular level, around organelles which are most exposed and most at risk of potential damage from oxidative stress from reactive oxygen species: mitochondria, peroxisomes and the nuclear matrix (Wu et al., 2004)

Although L-carnitine is generally safe for most people under normal conditions, there are certain groups who should avoid supplementation or consult a doctor before using it