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In fact, glutathione depletion is linked with a number of disease states and groups: Aging Athletic overtraining Major injuries and trauma Patients with wasting diseases such as HIV and AIDS Lung cancer Gut-based diseases such as Crohns and ulcerative colitis Chronic fatigue syndrome Alcoholism and fatty liver disease Diabetes and low glucose tolerance Cancer One of the most important things you can do to improve glutathione status is to remove or mitigate stressors that deplete glutathione

What to discuss : Patients with a family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) should avoid GLP-1 agonists

Similarly, patients with mild to moderate renal impairment may require closer monitoring during dose titration, though specific dose adjustments are not typically necessary based solely on renal function