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One small randomized controlled trial in 450 pregnant women in West Africa, without specified MTHFR genotype but at high risk for preeclampsia, found that supplementation with 15 mg of riboflavin daily was not effective in preventing the condition (29), but the study was likely underpowered to detect a significant effect
Riboflavins anti-inflammatory properties have mainly been studied using cell and murine models 43,45 , but are not yet well understood
Carries genuine hypoglycaemia risk
In pregnant women, maternal weight loss is harmful to fetal development, and amphetamine-like drugs may affect fetal growth
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