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The C201-harboring loop is also well-ordered in all three structures with the same degree of dynamical disorder found in the wild-type enzyme

Using this platform, they demonstrated that Aurora kinase inhibitors (AURKi) induce senescence in diffuse-type gastric cancer (DGC) cells and promote secretion of MCP-1/CCL2, which remodels the immune microenvironment and skews macrophages toward an M2 phenotype, contributing to therapeutic resistance