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Although appropriate measures were implemented to maintain blinding in the remaining PIONEER trials, it is possible that outcomes such as change in A1C and body weight, as well as safety outcomes known to be associated with GLP-1 receptor agonists such as nausea and other gastrointestinal AEs, may allow patients and investigators to infer which treatment was received

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Because the landscape continues to evolve, clinicians must verify current status before acting

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