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Prior pregnancy, menopause, medications and other age-related imbalances only add to the frustration

Muscle loss during weight loss When people lose weight on a GLP-1 medication, a portion of the weight loss comes from lean tissue, including muscle

Body composition affects distribution volume

It seems that weight loss will likely be very important for the benefits of the GLP-1 medicines in some conditions, and much less important, or not at all essential, for benefits in other disorders. According to Lane, although GLP-1 receptor agonists show promise in reducing cardiovascular risk factors, long-term cardiovascular safety trials are needed to assess cardiovascular mortality and events