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Most information comes from patient forums and social media, where reports are mixed: some describe renewed appetite suppression on re-start, while others report weight gain during breaks and significant nausea on resuming previous doses, often requiring a full re-titration

323 Isotopic tracer studies have shown that MAFLD patients exhibit increased de novo lipogenesis (DNL), that is respectively mediated by two transcription factors SREBP-1c and ChREBP

Diarrhea: Less common and typically intermittent, potentially due to dietary changes or the effect of semaglutide on the gastrointestinal tract lining

The STEP trials showed semaglutide producing 14.9% weight loss at 2.4mg weekly