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This approach is supported by FDA guidance on GLP-1 receptor agonist class labeling for semaglutide in renally impaired patients [11] and by the general pharmacodynamic rationale that slower CNS adaptation reduces nausea burden [10, 12]

Following the whole-organ imaging, the brain was further sectioned via sagittal slices (2-3mm thickness) into two and then four pieces to better visualize the brain regions that semaglutide is known to interact with