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Research uses MT-II alongside subtype-selective agonists and antagonists to establish how the combined activation of multiple melanocortin receptor subtypes simultaneously produces a different biological profile than selective activation of any single subtype and characterising the synergistic, additive, or redundant relationships between MC1R, MC3R, and MC4R-mediated biology
doi: 10.3389/fmed.2021.649408
7 Ermutlu C, Aksakal M, Gmta A, zkaya G, Kovalak E, zkan Y
Again, the significance of this is unclear but would warrant prolonged observation of diabetic patients on GLP-1 receptor agonists
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