These processes include: Glucuronidation, the most common Conjugation with amino acids Methylation Acetylation Conjugation with glutathione Sulfation1 Phase III The Gut-Microbiome Axis (The Estrobolome) Phase III is heavily influenced by the microbes in the gut, of which there are over 1,000 bacterial species in the colon, all influenced by food and medicine intake, immune system function, pathogens, and endocrine activity
The appetite suppression and rapid weight loss can reinforce restrictive eating patterns, increase body image preoccupation, and intensify disordered thoughts about food and weight
Delivery format is also widening the addressable market
Although the trial is not a conclusive verdict on semaglutides efficacy for addiction due to the small patient pool, and the results are far short of what would be needed for the FDA to formally approve the GLP-1 drugs use in alcohol use disorder, it does provide encouragement for companies who are thinking of testing their drugs in the indication in the not-so-distant future