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For liver-specific genetic deletions, mice were injected via the tail vein with 2.510 11 GC of AAV-TBG-Cre (Addgene, 107787-AAV8) in PBS

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2 Main TCMs as ferroptosis regulators in cancer 2.1 Terpenoids 2.1.1 Artemisinin and its derivatives 400 years ago, the famous Chinese herbalist Li Shi Zhen published in the Compendium of Materia Medica that fever and colds could be treated with qinghaosu preparations ( Artemisia annua by the Nobel laureate in Medicine and the Chinese scientist Tu Youyou in 1971, artemisinin has saved countless lives as an antimalarial drug ( Dihydroartemisinin (DHA), a derivative of artemisinin, can not only inhibit cell proliferation by inducing autophagy (Zou et al., 2019), but also exert its role by inhibiting the PRIM2/SLC7A11 axis and inducing ferroptosis (Yuan et al., 2020)