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The longest splicing variant of the SLC22A5 gene codes for an OCTN2 variant called OCTN2VT containing an insertion of 24 amino acids in the first extracellular loop, that seems to be localized in the ER (Figure 2

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In contrast, GPR55 mutations I156A 4.60 , N171A ECL2 , S173A 5.31 , F102A 3.33 , F159A 4.64 , and F246A 6.55 selectively decreased activation by LPI but not by curcumin, indicating that these residues play a lesser role in recognizing curcumin as a ligand