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Unlike native GLP-1, which has a half-life of only 1-2 minutes due to rapid enzymatic cleavage, the unique lipidization of the Semaglutide Peptide allows it to strongly bind to serum albumin, facilitating a substantially prolonged half-life for extended observational studies
BPI's argument expands upon Empower Pharmacys earlier challenge by introducing new prior art related to peptide design techniques that improve stability and reduce immunogenicityfactors they claim were already known before Lillys filing
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