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J.LiuJ.ZhangY.LiuY.et al
Your body needs to adapt to the glucagon receptor activation specifically, and no amount of GLP-1 tolerance from semaglutide or GLP-1/GIP tolerance from tirzepatide prepares you for that third receptor pathway
In 90-day tests, whether given through the diet (up to 9375 mg/kg BW/day) or by intramuscular injection (up to 0.5 ml/kg/day) in rabbits, no significant signs of toxicity were observed
Additional studies are exploring its use in patients already on immunosuppression (e.g., post-kidney transplant), which could broaden eligibility and reduce added risks
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