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This population represents a particularly challenging treatment group, as excess weight directly contributes to joint deterioration while joint pain limits physical activity

This gradual build-up, especially with initial dose increases during the first 4-8 weeks, helps in steadily reinforcing appetite control

The American Association of Clinical Endocrinology (AACE) Diabetes Management Algorithm 2023 recommends reviewing the full medication list at GLP-1/GIP agonist initiation with specific attention to narrow-therapeutic-index drugs