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This is a normal physiological response to weight loss regardless of the method used to achieve it, as documented in systematic reviews of energy expenditure during weight reduction

Compounded versions are made by individual pharmacies that may include other ingredients to address specific patient needs

Specific genetic variants (such as FTO rs9939609 and MC4R rs17782313) relate to how the body responds to metabolic signals, which can support understanding of digestive sensitivity alongside appetite response

Furthermore, the finding that symptom screening did not correlate with RGV suggests that current recommendations to rely on UGI symptom checks are likely insufficient