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The activation of Wnt/-catenin pathway can promote the proliferation and differentiation of mesenchymal stem cells and osteoblasts, increase cell activity and promote osteogenic differentiation (Wu et al., 2017) (Figure 1)

Nausea is a common side effect of semaglutide, and can range in intensity from mild to severe

It has been modified from the natural GLP-1 sequence to resist degradation by the enzyme DPP-4, which is why it lasts much longer in the body than natural GLP-1

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