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However, when semaglutide is used in combination with other antidiabetic agents that can cause hypoglycemia, such as sulfonylureas or insulin, the risk of hypoglycemia may increase

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The administration of DPP-4 inhibitors leads to a 2-3-fold elevation of endogenous GLP-1 concentration (9)

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It targets two systems at once (GLP-1 and GIP) which means it can actually produce more weight loss than semaglutide for some people

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In assessing tirzepatides safety, the FDA examined various aspects including potential side effects

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