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Molecular Ecology
Think different
Some of the SOD/catalase mimetics, e.g., SC-52608, SC-55858 (Valdivia et al., 2009), SC-54417 (Shimizu et al., 2003) (Figure 3B), will react selectively with superoxide, but not with other RS (e.g., hydroxyl radicals, hydrogen peroxide, nitric oxide, or peroxynitrite)
All the above evidences seem to have a clinical relevance: Polonikov, studying four moderate-severe COVID-19 cases, found that while the three patients with normal/high plasma levels of GSH recovered rapidly, the one with low GSH levels, high plasma ROS and ROS/GSH ratio experienced the most severe illness and, at the date of publication, was still sick (Polonikov, 2020)
