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However, the action of GLP-1 is glucose-dependent and blood glucose is only lowered by GLP-1 if concentrations are above fasting levels [40, 41]

Matveyenko AV et al

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Conclusion: Allo-LCA, with its potent dual action on GPBAR1 and RORt, reduces liver inflammation induced by an HFD + CCl 4 increasing insulin sensitivity and reducing liver fibrosis, suggesting that this compound may represent a potent new treatment for NASH and related fibrosis