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Factors such as dosing frequency, route of administration (injectable or oral), and potential side effects may influence the selection process
To achieve comparable effects, oral doses must be 30-50 times higher, creating cost and side effect challenges
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In healthy tissue, the peptide maintains NO homeostasis by modestly increasing endothelial NOS (eNOS) for beneficial vasodilation while suppressing inducible NOS (iNOS) that drives pathological inflammation
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