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By promoting the clearance of these dysfunctional cells, FOXO4-DRI holds promise as a therapeutic agent in rejuvenating tissues and improving healthspan

2021;372:eabf7258

With these robust findings, CagriSema has the potential to be the first amylin and GLP-1 combination therapy that addresses blood glucose control with reductions in bodyweight for people living with type 2 diabetes." Amylin, a pancreatic hormone co-secreted with insulin in response to food intake, plays a distinct yet complementary role to GLP-1, with potential roles in appetite, glycemic control, bone metabolism, and bodyweight

Improves insulin resistance in older individuals, increases mobility for people with peripheral artery disease and reduces symptoms of Parkinson's disease