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461 These neurons also demonstrate increased spontaneous activity independent of ascending afferent input and possess enlarged receptive fields, suggesting that thalamic neurons function as central generators or amplifiers of pain in DPN

The SELECT trial confirmed significant cardiovascular benefits alongside the weight loss

The ACC notes that clinicians should pay attention to gastrointestinal side effects, drug interactions, nutrition, and the patients overall cardiovascular situation when using GLP 1 therapies in practice

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