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GLP-1-RA such as Ex-4 and Liraglutide modulate multiple signaling pathways in hMSC and progenitor cells to enhance osteogenesis, suppress adipogenesis, promote survival, and reduce inflammation

Primarily indicated for type 2 diabetes: Ozempic Rybelsus Trulicity Victoza Byetta Bydureon Adlyxin Primarily indicated for chronic weight management: Wegovy Saxenda Zepbound Some active ingredients, such as semaglutide and tirzepatide, are available in separate branded formulations that carry different FDA-approved indications

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Current therapies, such as intraocular pressure (IOP)-lowering agents for glaucoma or anti-VEGF drugs for DR, primarily target symptoms rather than underlying neurodegeneration or chronic inflammation (Stein et al., 2021)