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When consuming fewer calories, the body may reduce non-essential energy expenditure, including heat production

10.1111/j.1572-0241.2001.03804.x 29 ChongP

Although these drugs would make Medicare beneficiaries healthy, preventing heart attacks, strokes, and kidney failure, the net impact would be higher medical costs

Lipodystrophy Administration of insulin subcutaneously, including insulin glargine products, has resulted in lipoatrophy (depression in the skin) or lipohypertrophy (enlargement or thickening of tissue) in some patients [see DOSAGE AND ADMINISTRATION ]