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In a 2026 comparative study, participants who took both a GLP-1 and levothyroxine experienced additional metabolic and cardiovascular effects compared to those who took only one of the two medications
Tapering the dose rather than stopping cold turkey may help mitigate the shock to the system, though evidence on this is still emerging
Eaton, W
Conclusion GLP-1 receptor agonists function as multi-system metabolic modulators that influence pathways intersecting with aging biology
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