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Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms
Therefore, GLP-1RA drugs like liraglutide or semaglutide can counteract DPP-4 degradation, prolonging the GLP-1R signal and maintaining insulin secretion via the mTOR-dependent HIF-1 pathway (34)
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