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Inhibition of DPP4 activity by synthetic inhibitors, such as those used to treat type 2 diabetes, results in suppression of T cell proliferation in vitro and a decrease in antibody production in vivo
This post-translational modification is now recognised as a major mechanism of redox-regulated cell signalling, controlling the activity of transcription factors, kinases, phosphatases, and metabolic enzymes in response to the intracellular redox environment
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Try a twoweek trial of different solutions, keeping one constant variable at a time: Diluted sports drink (half water, half sports drink) Powdered electrolyte tablets in sparkling water A homemade oral rehydration mix of 1 liter of water 1/2 teaspoon salt 2 tablespoons sugar Chilled and sipped slowly If sodium is a concern because of blood pressure, test lowsodium options and log symptoms
