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THEREFORE, clinical trial designers, investors, and regulators need to aim for more #clinicallyrelevant treatment target #endpoints beyond large magnitude wt loss, and also develop various drug #doses for the diverse intended populations and their different needs over time on their #weightmanagement journey

While the anti-inflammatory properties of GLP-1 therapy are promising, clinicians should counsel patients that definitive evidence for direct joint pain relief independent of weight loss is lacking

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A "soft" denial based on insufficient documentation or unmet criteria is much more likely to succeed on appeal because you can provide the missing information