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They are now commonly used when: Metformin alone is no longer enough Weight gain is contributing to worsening glucose control There is a need to minimise hypoglycaemia risk Someone has existing cardiovascular disease or multiple risk factors For many people, GLP-1 therapy can delay or reduce the need for insulin, or allow insulin doses to be kept lower and safer

doi:10.1542/peds.2024-068119

Rothstein JD, Van Kammen M, Levey AI, et al

L-arginine L-arginine is a conditionally essential amino acid, meaning it only has to be consumed in the diet under certain conditions, while healthy adults can make all they need ( It directly produces nitric oxide through a process called the L-arginine-NO pathway